After examining 50,000 patients, European scholars have discovered a gene profile associated with migraine. What to consider medication.

This is a serious hope for the 300 million people who suffer from migraine worldwide and 6.6 million French who are regularly achieved. An international group of geneticists specializing in headaches have identified a genetic variation in people prone to migraines. They published the results of their study August 31, 2010 on the website of the journal Nature Genetics .

Stress, fatigue

During crises, migraines suffer from nausea, vomiting, can not stand the light and sometimes lose sight temporarily. Among the triggers are known factors such as stress, lack of sleep, menstruation in women, food allergies or food too rich. In Europe, 17% of women and 8% of men suffer from headache.

50,000 migraine

For this study, which should pave the way for new drugs, researchers from 40 European research centers have joined forces to investigate the genetic profile of 50 000 migraines.


In chromosome 8

The researchers found that patients with variant-specific DNA located in chromosome 8 were prone to migraines. “This is the first time we are able to analyze the genomes of thousands of people and uncover clues enable us to understand genetic migraine ” said Dr Aarno Palotie, the Welcome Trust Sanger Institute in the UK.

Genetic variation relates to the regulation in the brain, the level of glutamate, a neurotransmitter known between neurons. Migraines suffer from excessive accumulation of these glutamate and achieve reduction would reduce by 20% the risk of migraine.

Family history

The migraine usually begins between 10 and 40 years, and found in 70% of cases of family history. The crisis usually starts in the morning, preceded by warning signs that allow patients to anticipate. Located half-skull sometimes left, sometimes right-pain intensity rises gradually to reach a plateau after a few hours. During the crisis, which often lasts a day, migraine has to lie in the dark, away from light or sound aggression. Sometimes hospitalization and put on oxygen, but also simple cold showers, relaxation techniques can relieve pain.

One billion euros

According to the website , headache cost a billion euros each year in France, Social Security. Absenteeism is an average of fifteen days with migraine per year: “Migraine represents 1% of total health system spending a year in France.” Approximately 19% of patients do not take any medication, 72% regularly consume and 9% sporadically. “This is the hospital that is the most common, 30% of migraine sufferers go there in case of crisis. Then come the sector specialist consultations, 20% drugs, 20% of para clinical examinations, 20% and finally Consultations GPs, 10%, ” says the site yet.